Missense, silent, non-sense and frame-shift mutations in exon 3 of the filaggrin gene in patients with bronchial asthma, atopic dermatitis, allergic rhinitis and mixed atopy

This study investigated the atopic march on basis of genetics. research detected 227 variants in filaggrin gene (FLG gene). Missense, silent, non-sense, frame-shift and non-coding mutations were exon 3 FLG patients with bronchial asthma, dermatitis, allergic rhinitis mixed atopy. Missense mutation was at c.8343 G > C (p. Asp2781Glu) all adult asthmatic patients. Whereas, c.8360 T/A Arg2787 His/Leu) childhood A c.12365 dermatitis asthma Furthermore, DNA sequencing showed missense c.6073 T Gly2025Glu) a silent c. 8341 Asp2781Asp).